External composition for skin



【課題】不全角化を抑制し、毛穴を縮小し、さらに肌荒れを防止・改善する等の優れた効果を有し、感覚刺激等の安全性上の問題がない、安全性の高い不全角化抑制剤、毛穴縮小剤、肌荒れ防止・改善剤、ならびに皮膚外用組成物の提供。 【解決手段】下記一般式(1)のピログルタミン酸誘導体及びその塩からなる群から選ばれる化合物の1種以上を含有する皮膚外用組成物。 (Xは、H、炭素数1〜3のアルキル基、アリル基、ベンジル基、ベンジルオキシカルボニル基又はベンゼンスルホニル基;Yは、OH、炭素数1〜3のアルコキシ基又はNR 1 R 2 ;R 1 及びR 2 は、H又は炭素数1〜3の炭化水素基、あるいはNR 1 R 2 が複素環を形成する。ただし、同時にXがHでYがOHではない。) 【選択図】なし
PROBLEM TO BE SOLVED: To provide a highly safe parakeratosis inhibitor, a pore-contracting agent, an agent for preventing and ameliorating skin roughness and an external composition for the skin, which are excellent in functions such as suppression of parakeratosis, contraction of pores and prevention, amelioration, etc., of skin roughness and causes no safety problems such as sensory irritation. SOLUTION: The external composition for the skin comprises at least one compound chosen from the group consisting of a pyroglutamic acid derivative of formula (1) (wherein X is H, a 1-3C alkyl group, an aryl group, a benzyl group, a benzyloxycarbonyl group or a benzenesulfonyl group; and Y is OH, a 1-3C alkoxy group or a group of the formula: NR 1 R 2 (wherein R 1 and R 2 are each H or a 1-3C hydrocarbon group, or NR 1 R 2 forms a heterocyclic ring), provided that when X is H, Y is not OH) and a salt thereof. COPYRIGHT: (C)2009,JPO&INPIT




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Cited By (2)

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    CN-103998424-AAugust 20, 2014陶氏环球技术有限责任公司制备烷基焦谷氨酸的方法
    WO-2013090591-A1June 20, 2013Dow Global Technologies LlcProcess for preparing alkyl pyroglutamic acids